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Limitations of 2000mg: Capsule forms at 2000mg can sometimes cause mild GI discomfort initially Not always necessary for sedentary individuals Should ideally be paired with consistent physical activity to maximise fat metabolism Ideal for: Regular gym users, people in the plateau phase of fat loss, runners, cyclists, and intermediate-level athletes

In addition to mass, lipophilicity, and the presence of hydrogen bonds, the charge and polar surface area of the compound can also influence the associated BBB permeability (6, 44)

These include: Renal impairment impaired kidneys cannot clear excess magnesium and other minerals safely G6PD deficiency high-dose vitamin C can trigger haemolytic anaemia in these patients Congestive heart failure fluid overload risk with IV administration